Advancements in Sensor Technologies for Microfluidic Systems: Implications for Drug Discovery and Plant Pathogen Detection
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Abstract
Microfluidic systems integrated with sensors have shown great promise for applications in drug discovery and plant pathogen detection. Recent advancements in sensor technologies including electrochemical, optical, mechanical, and mass sensitivity detectors have enabled accurate, rapid, and cost-effective analysis of biochemical samples on microfluidic chips. The integration of microfluidics with sensors provides capability for high-throughput analysis, portability, reduced sample requirements, and process automation. The small dimensions of microfluidic channels allow precise manipulation of very small volumes of fluids, facilitating automation. This article reviews recent research on novel microfluidics-based sensors and their emerging implications on pharmaceutical research and agriculture. For drug discovery, microfluidic platforms with embedded sensors enable refined in vitro models that better emulate human physiology for reliable toxicity assessment and drug screening. Lab-on-chip microfluidic sensors with capabilities in nanoliter sample volumes are also cutting analysis times and costs in the discovery pipeline. High-throughput screening against large compound libraries and optimizing synergistic combinations of drug candidates is now possible. For plant pathogen screening, microfluidic immunoassays and molecular diagnostic devices facilitate rapid, sensitive and portable detection alternatives to conventional laboratory-based screening tools. Smartphone-readable microfluidic sensor strips are creating opportunities for instant field tests without requiring extensive supporting infrastructure. Future priorities focus on expanding organ and disease models, mobile diagnostics for on-site analysis, smartphone integration, process automation, training provisions, and cross-disciplinary collaborations to translate more microfluidic sensors from lab to application. Overall, microfluidics-integrated sensor technologies promise to transform drug development and agriculture landscape through early disease diagnosis, toxicology prediction, and precise interventions during disease/treatment stages.
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Last updated: 05-02-2023